The 'pan-genome' denotes the set of all genes present in the genomes of a group of organisms. Here, we extend the pan-genome concept to higher taxonomic units. Using 573 sequenced genomes, we estimate the size of the bacterial pan-genome based on the frequency of occurrences of genes among sampled genomes. Using gene- and genome-centered approaches, we characterize three distinct pools of gene families that comprise the bacterial pan-genome, each evolving under different evolutionary constraints. Our findings indicate that the pan-genome of the bacterial domain is of infinite size (the Bacteria as a whole have an open pan-genome) and that ???250 genes per genome belong to the extended bacterial core genome. ?? 2008 Elsevier Ltd. All rights reserved.
Santos, M. E. R., Da Fonseca, D. M., Gomes, V. M., Balbino, E. M., & Magalhães, M. A. (2010). Estrutura do capim-braquiária durante o diferimento da pastagem. Acta Scientiarum - Animal Sciences, 32(2), 139–145. https://doi.org/10.4025/actascianimsci.v32i2.7922