Cardiovascular diseases have been associated with genetic variants and increased plasma level of the secreted protein PCSK9. In this issue of Cell Chemical Biology, Petersen et al. (2016) describe an inhibitor of PCSK9 secretion in human cells that, surprisingly, targets the 80S ribosome.
Pellegrino, S., & Yusupova, G. (2016, November 17). Eukaryotic Ribosome as a Target for Cardiovascular Disease. Cell Chemical Biology. Elsevier Ltd. https://doi.org/10.1016/j.chembiol.2016.11.004