Evaluation of effectiveness of vitamins C and e on prevention of renal scar due to pyelonephritis in rat

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Abstract

Aim was evaluation of the effects of cosupplementation of, vitamins E and C, in preventing renal scarring in acute pyelonephritis. Animals and Treatments . Sixty rats were used, bacteria was injected through kidney. The rats were arranged randomly in 3 groups of 20 rats each. Rats in groups 1 and 2 were given once-daily intraperitoneal injections of gentamicin for ten consecutive days, beginning on the third day after inoculation. In group 2, vitamins E and C cotreatment and in group 3, vitamins E and C cotreatment without gentamicin injection were started. Three rats in each group were killed 24 hours after the inoculation (for infection and inflammation document) and forty-eight hours after the antibiotic injection (for efficacy of treatment). After eight weeks, the rest of rats were killed, and kidneys evaluated for percent of scaring. Result . There was also significant difference of degree of scar formation (1.4 and 3.4% versus 8.6%, ). The group which received gentamicin only had moderate to severe scaring, but the two groups which received vitamin C and vitamin E showed no or mild renal scaring. Conclusion . The study showed that administration of antioxidants can protect scaring due to pyelonephritis with or without antibiotic administration.

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Emamghorashi, F., Owji, S. M., & Motamedifar, M. (2011). Evaluation of effectiveness of vitamins C and e on prevention of renal scar due to pyelonephritis in rat. Advances in Urology. https://doi.org/10.1155/2011/489496

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