Evaluation of invitro α-amylase and α-glucosidase inhibitory potential of N2O2 schiff base Zn complex

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Abstract

The evaluation of the antioxidant, antibacterial and enzyme inhibition effects of N2O2 Schiff base Zn complex was investigated. The percentage scavenging activity of hydroxyl radical (IC50-0.21 μg), ABTS (IC50-0.19 μg) and DPPH (IC50-0.25 μg) shows that ZnL complex had a potential antioxidant activity. The antibacterial activity of ZnL complex was evaluated. Results showed that MIC value against Staphylococcus aureus and Salmonella typhi was 100 and 200 μg/ml, respectively. ZnL complex showed strong inhibition toward α-amylase and α-glucosidase with an IC50 value of 0.18 and 0.23 μg, respectively. The inhibition mechanism was analyzed with LB and Dixon plots. The ZnL complex could be a mixed noncompetitive and noncompetitive inhibitor with Ki values of 77.8 and 31.6 μg for α-amylase and α-glucosidase, respectively. The preliminary assessment of ZnL complex showed that they can be used as an antioxidant, antibacterial and antidiabetic agents.

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Balan, K., Ratha, P., Prakash, G., Viswanathamurthi, P., Adisakwattana, S., & Palvannan, T. (2017). Evaluation of invitro α-amylase and α-glucosidase inhibitory potential of N2O2 schiff base Zn complex. Arabian Journal of Chemistry, 10(5), 732–738. https://doi.org/10.1016/j.arabjc.2014.07.002

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