Objective: To study the effects of reducing hemorrhage by loop ligation of larger myoma pseudocapsules combined with vasopressin on laparoscopic myomectomy (LM). Design: Prospective controlled clinical trial. Setting: Sheng Jing Hospital, China Medical University. Patient(s): A total of 105 women with symptomatic single or multiple larger myomas (diameter 6-18 cm) in need of surgical intervention, who wished to retain their uteri, were randomly divided into three groups in our hospital from January 2006 to January 2008: A) loop ligation combined with vasopressin; B) vasopressin alone; and C) neither loop ligation nor vasopressin. All patients were treated by LM. Each group included 35 cases. Intervention(s): Loop ligation of larger myoma (6-18 cm) pseudocapsule combined with vasopressin before thoroughly enucleating the myoma. Main Outcome Measure(s): Operating time, blood loss, blood transfusion, postoperative stay in hospital, symptom improvement. Result(s): Average blood loss, postoperative stay in hospital, number of conversions to laparotomy, and need for transfusion because of bleeding during operation in group A were significantly lower than in groups B and C. All patients in group A underwent technically successful laparoscopic operations. Conclusion(s): Loop ligation of larger myoma pseudocapsules combined with vasopressin is a safe, effective, and promising new method to reduce bleeding during laparoscopic myomectomy and makes the laparoscopic operations with larger myomas easier. © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.
Zhao, F., Jiao, Y., Guo, Z., Hou, R., & Wang, M. (2011). Evaluation of loop ligation of larger myoma pseudocapsule combined with vasopressin on laparoscopic myomectomy. Fertility and Sterility, 95(2), 762–766. https://doi.org/10.1016/j.fertnstert.2010.08.059