EvoIvability and single-genotype fluctuation in phenotypic properties: A simple heteropolymer model

Citations of this article
Mendeley users who have this article in their library.


Experiment showed that the response of a genotype to mutation, i.e., the magnitude of mutational change in a phenotypic property, can be correlated with the extent of phenotypic fluctuation among genetic clones. To address a possible statistical mechanical basis for such phenomena at the protein level, we consider a simple hydrophobic-polar lattice protein-chain model with an exhaustive mapping between sequence (genotype) and conformational (phenotype) spaces. Using squared endto-end distance, RN2, as an example conformational property, we study how the thermal fluctuation of a sequence's RN2 may be predictive of the changes in the Boltzmann average (RN2) caused by single-point mutations on that sequence. We found that sequences with the same ground-state (R N2 exhibit a funnel-like organization under conditions favorable to chain collapse or folding: fluctuation (standard deviation a) of RN2 tends to increase with mutational distance from a prototype sequence whose (RN2) deviates little from its (RN2. In general, large mutational decreases in (RN2) or in a are only possible for some, though not all, sequences with large a values. This finding suggests that single-genotype phenotypic fluctuation is a necessary, though not sufficient, indicator of evolvability toward genotypes with less phenotypic fluctuations. © 2010 by the Biophysical Society.




Chen, T., Vernazobres, D., Yomo, T., Bornberg-Bauer, E., & Chan, H. S. (2010). EvoIvability and single-genotype fluctuation in phenotypic properties: A simple heteropolymer model. Biophysical Journal, 98(11), 2487–2496. https://doi.org/10.1016/j.bpj.2010.02.046

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free