The evolution of medulloblastoma therapy to personalized medicine

  • Pomeroy S
  • Sengupta S
  • Pomeranz Krummel D
Citations of this article
Mendeley users who have this article in their library.
Get full text


© 2017 Sengupta S et al. Recent advances in cancer genomics have revolutionized the characterization and classification of medulloblastomas. According to the current WHO guidelines, medulloblastomas are now classified into the following molecularly defined groups: Wnt signaling pathway (WNT)-activated, sonic hedgehog signaling pathway (SHH)-activated and tumor suppressor protein p53 (TP53)-mutant, SHH-activated and TP53-wildtype, and non-WNT/non-SHH (i.e. group 3 and group 4). Importantly, genomic, epigenomic, and proteomic advances have created a potential paradigm shift in therapeutic options. The challenge now is to (i) translate these observations into new therapeutic approaches and (ii) employ these observations in clinical practice, utilizing the classification following a molecular analysis for diagnosis and application of new subgroup-specific targeted therapeutics.




Pomeroy, S., Sengupta, S., & Pomeranz Krummel, D. (2017). The evolution of medulloblastoma therapy to personalized medicine. F1000Research, 6.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free