Evolutionary new sequences expressed in tumors

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Background: Earlier we suggested the concept of the positive evolutionary role of tumors. According to this concept, tumors provide conditions for the expression of evolutionarily new and/or sleeping genes in their cells. Thus, tumors are considered as evolutionary proving ground or reservoir of expression. To support this concept we have previously characterized in silico and experimentally a new class of human tumor-related transcribed sequences. Results: In this article we describe results of further studies of previously described tumor-related sequences. The results of molecular phytogeny studies, Southern hybridization experiments and computational comparison with genomes of other species are presented. Conclusion: These results suggest that these previously described tumor-related human transcripts are also relatively evolutionarily new.




Kozlov, A. P., Galachyants, Y. P., Dukhovlinov, I. V., Samusik, N. A., Baranova, A. V., Polev, D. E., & Krukovskaya, L. L. (2006). Evolutionary new sequences expressed in tumors. Infectious Agents and Cancer, 1(1). https://doi.org/10.1186/1750-9378-1-8

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