Excitation-inhibition discoordination in rodent models of mental disorders

Citations of this article
Mendeley users who have this article in their library.
Get full text


Animal models of mental illness provide a foundation for evaluating hypotheses for the mechanistic causes of mental illness. Neurophysiological investigations of neural network activity in rodent models of mental dysfunction are reviewed from the conceptual framework of the discoordination hypothesis, which asserts that failures of neural coordination cause cognitive deficits in the judicious processing and use of information. Abnormal dynamic coordination of excitatory and inhibitory neural discharge in pharmacologic and genetic rodent models supports the discoordination hypothesis. These observations suggest excitation-inhibition discoordination and aberrant neural circuit dynamics as causes of cognitive impairment, as well as therapeutic targets for cognition-promoting treatments.




Fenton, A. A. (2015, June 15). Excitation-inhibition discoordination in rodent models of mental disorders. Biological Psychiatry. Elsevier USA. https://doi.org/10.1016/j.biopsych.2015.03.013

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free