Exercise-induced bone formation is poorly linked to local strain magnitude in the sheep tibia

27Citations
Citations of this article
42Readers
Mendeley users who have this article in their library.

Abstract

Functional interpretations of limb bone structure frequently assume that diaphyses adjust their shape by adding bone primarily across the plane in which they are habitually loaded in order to minimize loading-induced strains. Here, to test this hypothesis, we characterize the in vivo strain environment of the sheep tibial midshaft during treadmill exercise and examine whether this activity promotes bone formation disproportionately in the direction of loading in diaphyseal regions that experience the highest strains. It is shown that during treadmill exercise, sheep tibiae were bent in an anteroposterior direction, generating maximal tensile and compressive strains on the anterior and posterior shaft surfaces, respectively. Exercise led to significantly increased periosteal bone formation; however, rather than being biased toward areas of maximal strains across the anteroposterior axis, exercise-related osteogenesis occurred primarily around the medial half of the shaft circumference, in both high and low strain regions. Overall, the results of this study demonstrate that loadinginduced bone growth is not closely linked to local strain magnitude in every instance. Therefore, caution is necessary when bone shaft shape is used to infer functional loading history in the absence of in vivo data on how bones are loaded and how they actually respond to loading. © 2014 Wallace et al.

Cite

CITATION STYLE

APA

Wallace, I. J., Demes, B., Mongle, C., Pearson, O. M., Polk, J. D., & Lieberman, D. E. (2014). Exercise-induced bone formation is poorly linked to local strain magnitude in the sheep tibia. PLoS ONE, 9(6). https://doi.org/10.1371/journal.pone.0099108

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free