Exon Skipping Is Correlated with Exon Circularization

112Citations
Citations of this article
143Readers
Mendeley users who have this article in their library.

Abstract

Circular RNAs are found in a wide range of organisms and it has been proposed that they perform disparate functions. However, how RNA circularization is connected to alternative splicing remains largely unexplored. Here, we stimulated primary human endothelial cells with tumor necrosis factor α or tumor growth factor β, purified RNA, generated > 2.4 billion RNA-seq reads, and used a custom pipeline to characterize circular RNAs derived from coding exons. We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome.

Cite

CITATION STYLE

APA

Kelly, S., Greenman, C., Cook, P. R., & Papantonis, A. (2015). Exon Skipping Is Correlated with Exon Circularization. Journal of Molecular Biology, 427(15), 2414–2417. https://doi.org/10.1016/j.jmb.2015.02.018

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free