Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, and nearly 40% of UM will develop metastasis that will ultimately lead to death. The Epithelial Cell Adhesion Molecule (EpCAM) is a type I transmembrane glycoprotein expressed by carcinomas of head and neck, ovary, colon, breast, kidney and lung. Recently, antibodies against EpCAM such as Edrecolomab and Catumaxomab were developed, and clinical trials with these antibodies have been used in several types of neoplasia. We studied the expression of EpCAM in UM.
Odashiro, D. N., Odashiro, A. N., Pereira, P. R., Godeiro, K., Antecka, E., Di Cesare, S., & Burnier, M. N. (2006, November 24). Expression of EpCAM in uveal melanoma. Cancer Cell International. https://doi.org/10.1186/1475-2867-6-26