Expression of HNF4α isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3′ end splicing

63Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

Abstract

Hepatocyte nuclear factor 4α (HNF4α) is essential for the establishment and maintenance of liver-specific gene expression. The HNF4α gene codes for several isoforms whose developmental and physiological relevance has not yet been explored. HNF4α1 and HNF4α7 originate from different promoters, while alternative splicing in 3′ leads to HNF4α2 and HNF4α8, respectively. HNF4α7/α8 were abundantly expressed in embryonic liver and fetal-like hepatoma cells. HNF4α1/α2 transcripts were up-regulated at birth and represented the only isoforms in adult-like hepatoma cells. In line with its expression profile, HNF4α7 activated more avidly than HNF4α1 reporter plasmids for genes that are expressed early. The expression patterns of both isoforms together with the differences observed in their transcriptional activities provide elements accounting for fine-tuning of the activity of HNF4α. The sequential expression of HNF4α7/α8 and HNF4α1/α2 during mouse liver development is the only modification in liver-enriched transcription factors thus far recorded, which parallels the transition from the fetal to the adult hepatic phenotype. © 2001 Elsevier Science Ireland Ltd. All rights reserved.

Cite

CITATION STYLE

APA

Torres-Padilla, M. E., Fougère-Deschatrette, C., & Weiss, M. C. (2001). Expression of HNF4α isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3′ end splicing. Mechanisms of Development, 109(2), 183–193. https://doi.org/10.1016/S0925-4773(01)00521-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free