Extracellular superoxide dismutase and cardiovascular disease

230Citations
Citations of this article
110Readers
Mendeley users who have this article in their library.

Abstract

Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2•-), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•- are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases. © 2002 Elsevier Science B.V. All rights reserved.

Cite

CITATION STYLE

APA

Fukai, T., Folz, R. J., Landmesser, U., & Harrison, D. G. (2002). Extracellular superoxide dismutase and cardiovascular disease. Cardiovascular Research. https://doi.org/10.1016/S0008-6363(02)00328-0

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free