Extracellular superoxide dismutase and cardiovascular disease

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Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2•-), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•- are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases. © 2002 Elsevier Science B.V. All rights reserved.




Fukai, T., Folz, R. J., Landmesser, U., & Harrison, D. G. (2002). Extracellular superoxide dismutase and cardiovascular disease. Cardiovascular Research. https://doi.org/10.1016/S0008-6363(02)00328-0

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