Cyclometalated platinum(ii) complex as a selective light switch for G-quadruplex DNA

Abstract

Cyclometalated 1,3-bis(8-quinolyl) phenyl chloroplatinum(ii) (Pt1) shows selective luminescence transduction of G-quadruplex binding over duplex DNA. The effect is enhanced on association with parallel and hybrid G-quadruplex structures over other topologies. The kinetics of binding are studied for c-myc and the response is found to be partially reversible in a displacement assay.