NK/NKT cells and aging

Abstract

Aging involves a complex physiologic process including a decline of immune function that may contribute to morbidity and mortality due to increased susceptibility to infection, cancer, and other immune-related diseases. Natural killer (NK) and natural killer T (NKT) cells play an important role in regulating innate and adaptive immune response, their cytotoxicity being effective to kill infected cells and even tumors. Age-related alterations of NK and NKT cells in their numbers and activities have been reported, with significant association with infection control and life satisfaction in the elderly. This review introduces NK/NKT cells and aging and discusses the correlation between these cells and aging. Finally, potential therapeutic strategies and nutrients in regulating NK/NKT cells and aging are described for the control of immune response, for healthy aging and longevity. © 2007 Elsevier.