Treatment of Mansonella perstans infection, although seldom necessary, is difficult. In a 3 year's trial of normal and high-dose annual and 3-monthly ivermectin treatment against Onchocerca volvulus, the effects on M. perstans were recorded and related to the cumulative dose received. The World Health Organization's African Programme for Onchocerciasis Control may thus reduce the endemicity of M. perstans.
Gardon, J., Kamgno, J., Gardon-Wendel, N., Demanga-Ngangue, A., Duke, B. O. L., & Boussinesq, M. (2002). Efficacy of repeated doses of ivermectin against Mansonella perstans. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96(3), 325–326. https://doi.org/10.1016/S0035-9203(02)90112-4