Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase

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Abstract

MAK-V/Hunk is a scantily characterized AMPK-like protein kinase. Recent findings identified MAK-V as a pro-survival and anti-apoptotic protein and revealed its role in embryonic development as well as in tumorigenesis and metastasis. However molecular mechanisms of MAK-V action and regulation of its activity remain largely unknown. We identified Nedd4 as an interaction partner for MAK-V protein kinase. However, this HECT-type E3 ubiquitin ligase is not involved in the control of MAK-V degradation by the ubiquitin-proteasome system that regulates MAK-V abundance in cells. However, Nedd4 in an ubiquitin ligase-independent manner rescued developmental defects in Xenopus embryos induced by MAK-V overexpression, suggesting physiological relevance of interaction between MAK-V and Nedd4. This identifies Nedd4 as the first known regulator of MAK-V function. © 2012 Kalinichenko et al.

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Kalinichenko, S. V., Itoh, K., Korobko, E. V., Sokol, S. Y., Buchman, V. L., & Korobko, I. V. (2012). Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase. PLoS ONE, 7(6). https://doi.org/10.1371/journal.pone.0039505

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