Biochemical Assessment As Markers For Diagnosis And Evaluation Hepatitis B Virus (HBV)

Abstract

Background. Chronic hepatitis B virus (HBV) infection is a major cause of liver morbidity and mortality worldwide. many others risk developing complications of the end-stage liver disease such as decompensated cirrhosis and hepatocellular carcinoma (HCC), without intervention. This study aimed to assess biochemical markers for the development of hepatitis B viruses (HBV), in which any possible connection between certain biochemical parameters and chronic hepatitis was identified. Liver function tests help diagnose liver disease and dysfunction, assess severity, tracking treatment, and determining prognosis. Methods. A total of (200) patients with CHB were admitted to Hepatology and Gastroenterology Teaching Hospital in Baghdad from the first of March to the end of May 2021, aged from 20-65 years by mean±.SD 31y. The patients were suffering from different clinical symptoms with previous risk factors for transmission of HBV infection. compare with a total of 100 healthy HBs Ag carriers aged from 18-52 years by mean45.06y. According to the findings of biochemical studies, chronic patients have higher levels of ALP, GPT, GOT, and TSB than carriers. The outcome of biochemical tests indicates that the ALP, GPT, GOT and TSB are higher in CHB patients than carrier group and their values are ALK. phosph KAU [(22.9±8.5) and (10.1±3.2)], GPT IU/l [(45.2±18.2) and (13.8±4.0)], GOT IU/l [(30.6±11.1) and (13.5±4.3)] and TSB mg/dl [(3.5±1.9) and (0.9±0.3)] respectively with highly significant difference (P<0.001) The rise in liver enzymes strongly indicates hepatocellular damage, even though ALP, GPT, GOT, and TSB levels in the carrier group were all within normal parameters as compared to the reference group. Testing liver function in terms of protein level, in conclusion, these findings may cast new light on immune response especially related to deficiencies of liver synthesis of acute-phase proteins and antioxidant enzyme involvement in viral infections and HBV biology.