Mesoporous Silica Nanoparticles (MSN): A Nanonetwork and Hierarchical Structure in Drug Delivery

  • jadhav K
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Abstract

important roles in modern science and technology, including pharmaceutical science. Mesoporous materials in particular have a large number of applications. In the past decade, mesoporous silica nanoparticles (MSNs) attracted attention increasingly for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs have significant advantages as drug delivery systems (DDSs) compared with traditional drug nanocarriers. Inorganic mesoporous materials are being used increasingly in pharmaceutical materials research to enhance the dissolution and permeation behavior of drugs that are poorly soluble in water. The benefits of using mesoporous materials in drug delivery applications stem from their large surface area and pore volume. These properties enable the materials to accommodate large amounts of payload molecules, protect them from premature degradation and promote controlled and fast release. As carriers with various morphologies and chemical surface properties can be produced, these materials may even promote adsorption from the gastrointestinal tract to the systemic circulation. In this work, we review recent progress in the synthesis and surface functionalization of MSNs for drug delievery applications.

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jadhav, komal. (2015). Mesoporous Silica Nanoparticles (MSN): A Nanonetwork and Hierarchical Structure in Drug Delivery. Journal of Nanomedicine Research, 2(5). https://doi.org/10.15406/jnmr.2015.02.00043

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