Revealing hyperactivated IFN-γ pathways in perianal fistulizing Crohn’s disease using single-cell and spatial multi-omics

Siyan Cao; Khai M. Nguyen; Kaiming Ma; Tingyi Tan; Xin Yao; Ta Chiang Liu; Malek Ayoub; Jalpa Devi; Sami Samaan; Yizhou Liu; Radhika Smith; Matthew L. Silviera; Steven R. Hunt; Paul E. Wise; Matthew G. Mutch; Sean C. Glasgow; William C. Chapman; Michelle L. Cowan; Matthew A. Ciorba; Marco Colonna; Parakkal Deepak

Journal ArticleOPEN ACCESS

Revealing hyperactivated IFN-γ pathways in perianal fistulizing Crohn’s disease using single-cell and spatial multi-omics

Journal of Clinical Investigation (2025) 135(17)

DOI: 10.1172/JCI193413

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Cao, S., Nguyen, K. M., Ma, K., Tan, T., Yao, X., Liu, T. C., … Deepak, P. (2025). Revealing hyperactivated IFN-γ pathways in perianal fistulizing Crohn’s disease using single-cell and spatial multi-omics. Journal of Clinical Investigation, 135(17). https://doi.org/10.1172/JCI193413

Revealing hyperactivated IFN-γ pathways in perianal fistulizing Crohn’s disease using single-cell and spatial multi-omics

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