Analisis Senyawa Obat dalam Sampel Biologis Plasma Darah

Abstract

In this journal review, we used different drug compounds from the same biological sample, namely plasma with amoxicillin, glyciburida, vancomycin, amlodipine, and paracetamol. Chromatography-Mass Spectrometry (GC-MS). For the first compounds of amoxicillin, plasma concentrations were measured at 250 g/mL and 500 g/mL, and each concentration was repeated 3 times. Glyciburida, plasma concentration is determined by 3 concentrations namely 1g / mL, 2g / mL and 4g / mL, and each concentration is repeated 5 times. For Vanskomin, 4 concentrations are used for the determination of plasma concentrations, namely 3 g / mL, 15 g / mL, 31.5 g / mL and 48 g concentrations that are suitable for the determination of amoxicillin, which is a level of 500 g / mL. All concentrations are suitable for glyburide determination All concentrations are suitable for glyburide determination The most accurate method is the liquid chromatography/mass spectrometry method (LC/MS), and acetaminophen uses gas chromatography-mass spectrometry (GC/MS) method.-MS), the level of paracetamol in the blood sample obtained is 175.2 ppm.