An efficient chemoenzymatic synthesis of the bactericide lapyrium chloride

Abstract

An efficient route for large-scale preparation of lapyrium chloride, a broad-spectrum antimicrobial surfactant, was developed from chloroacetic acid in four steps, three of them enzymatic. Due to the chemoselective behavior of the biocatalysts, lapyrium chloride was obtained in a high degree of purity and yield, from mild reaction conditions and following a low environmental impact methodology. © Wiley-VCH Verlag GmbH & Co. KGaA, 2005.