Translation Enhancement of m-Rna by Immuno Evasion Proteins

Abstract

In this paper, mono-functional EKB i.e. “E3”, “K3” and “B18R” derived from vaccinia virus is compared with multi-functional NS1 derived from “influenza A virus” to compare their ability for the enhancement of the mRNA translation. Further, expression of luciferase was transferred by delivery of unmodified luciferase assorted with NS1 mRNA and compared with delivery of unmodified luciferase assorted with either “E3”, “K3” or “B18R” respectively. Various combination of “E3”, “K3”, “B18R” were assorted with NS1-TX91 mRNA at different ratios and delivered with m RNA of luciferace.