Streamlined Synthesis of Bulky (Dispersion Energy Donor) Iodobenzenes

Abstract

We report an efficient synthesis of meta-substituted iodobenzenes from readily available starting materials. Negishi coupling utilizing Knochel’s protocol followed by iodination provides the desired compounds in excellent yields over two steps from readily available precursors. These iodobenzenes equipped with dispersion energy donors serve as building blocks for catalysts as demonstrated in the Corey–Bakshi–Shibata reduction.