Background: Cellular communication is an essential feature of multicellular organisms. Binding of ligands to their homologous receptors, which activate specific cell signaling pathways, is a basic type of cellular communication and intimately linked to many degeneration processes leading to diseases. Main body: This study reviewed the history of ligand-receptor and presents the databases which store ligand-receptor pairs. The recently applications and research tools of ligand-receptor interactions for cell communication at single cell level by using single cell RNA sequencing have been sorted out. Conclusion: The summary of the advantages and disadvantages of analysis tools will greatly help researchers analyze cell communication at the single cell level. Learning cell communication based on ligand-receptor interactions by single cell RNA sequencing gives way to developing new target drugs and personalizing treatment.
CITATION STYLE
Ma, F., Zhang, S., Song, L., Wang, B., Wei, L., & Zhang, F. (2021, December 1). Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level. Cell and Bioscience. BioMed Central Ltd. https://doi.org/10.1186/s13578-021-00635-z
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