Angiographic Coronary Calcification: A Simple Predictor of LongTerm Clinical Outcomes in Patients with Acute Myocardial Infarction

Abstract

Aims: Coronary calcification detected by coronary angiography is a simple risk marker for long-term clinical outcomes in stable coronary artery disease. However, the significance of angiographic coronary calcification in the culprit lesion of acute myocardial infarction (AMI) has not been fully discussed. The purpose of this retrospective study was to assess the usefulness of angiographic coronary calcification as a risk marker for longterm clinical outcomes following percutaneous coronary intervention to the culprit lesions of AMI. Methods: We included 1209 patients with AMI and divided them into the none–mild calcification group (n=923) and the moderate–severe calcification group (n=286) according to angiographic coronary calcification in the culprit lesion of AMI. The primary endpoint was the occurrence of major adverse cardiac events (MACE), which was defined as a composite of all-cause death, nonfatal MI, readmission for heart failure, and ischemiadriven target vessel revascularization. Results: The median follow-up duration was 542 (Q1: 182, Q3: 990) days. A total of 345 MACE were observed during the study period. The occurrence of MACE was significantly greater in the moderate–severe calcification group than in the none–mild calcification group (43.4% vs. 23.9%, p＜0.001). In the multivariate Cox hazard model, moderate–severe calcification was significantly associated with MACE (hazard ratio 1.302, 95% confidence interval 1.011–1.677, p=0.041) after controlling multiple confounding factors. Conclusions: Angiographically moderate to severe calcification in AMI culprit lesion was associated with longterm worse clinical outcomes. Angiographic coronary calcification can be a simple risk marker in patients after AMI.