Rehabilating activity of mangiferin in Benzo(a) Pyrene induced lung carcinogenesis

Abstract

Cancer chemoprevention involves prevention, delay, or reversal of the process of carcinogenesis through ingestion of dietary or pharmaceutical agents. A large number of potential chemopreventive agents are known, some of which have proven affective in clinical trial. These agents may function by a vanery of mechanism directed at all major stages on carcenogenesis. One mechanism of particular note involves the inhibition of biosynthesis of polyamines such as spermine, spermidine and putrescine are promising drug for chemoprevention, In the present study we evaluate chemopreventive efficacy of mangifenn against Benzo(a)Pyrene (B(a)P) induced Ring carcinogenesis. Male Swiss albino mice strains were selected for the present investigation. Lung carcinoma was induced with B(a) P (50 mg kg-1 body weight, orally) and the treatment was started by the oral administration, of mangiferin (100 mg kg-1 body, weight). The modulatory effect of the mangiferin was examined on lung and liver to evaluate the level of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation. Mangiferin significantly decreased the levels of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation that were found to be increased in lung cancer bearing animals. Mangiferin could effectively inhibit B(a)P-induced lung carcinogenesis in albino mice by offering protection from protein damage and also by suppressing cell proliferation. © 2008 Academic Journals Inc.