Background: Low FODMAP (Fermentable Oligo-, Di-, Monosaccharides and Polyols) diet (LFD) has been shown to be efficient in irritable bowel syndrome (IBS). The objective of this study was to investigate the impact of a LFD on IBS-like symptoms, disease activity and quality of life in inflammatory bowel disease (IBD) (SIBDQ). Methods: Randomised, non-blinded controlled six weeks trial of IBD patients in remission or mild to moderate disease activity and IBS-like symptoms (Rome III criteria) were allocated to either LFD or normal diet. Patients had to fill out the IBS symptom severity scale (IBS-SSS) and quality of life (IBS-QOL) at week 0 and 6 on a web-based program and IBD activity symptom scores: SCCAI for ulcerative colitis (UC), HBI for Crohn's disease (CD) and quality of life (SIBDQ) on paper. Results: A total of 89 patients: 61 (69%) UC and 28 (21%) CD, 67 (75%) females, median age 40 years (20-70) were randomized: 44 to LFD and 45 as controls. Significant reduction in IBS-SSS at week 6 in LFD compared to controls (114 vs. 68), p = 0.02 was observed. In UC a significant reduction of SCCAI (0.7 vs. 0.1), p = 0.02 but not in CD was observed. SIBDQ improved significantly in LFD (9.1-0.9), p < 0.001. Conclusions: LFD is effective in IBD patients in remission or mild-to moderate activity, predominantly improving IBS-like symptoms in patients and further reduce disease activity for UC and improve SIBDQ.
Pedersen, N., Felding, M., Ankersen, D., Vegh, Z., Burisch, J., & Munkholm, P. (2014). DOP067 Low FODMAP diet reduces irritable bowel symptoms and improves quality of life in patients with inflammatory bowel disease in a randomized controlled trial. Journal of Crohn’s and Colitis, 8, S47. https://doi.org/10.1016/s1873-9946(14)60092-1