Adipose Derived Stem Cells and Growth Factors Applied on Hair Transplantation. Follow-Up of Clinical Outcome

  • Zanzottera F
  • Lavezzari E
  • Trovato L
  • et al.
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Different studies show the need\r<br />of immature adipose cell to induce the proliferation of bulge stem cells in\r<br />order to kick off the anagen phase of hair cycle. Furthermore, the adipose\r<br />derived stem cell, adipose progenitors, and growth factors secreted by mature\r<br />adipocytes can help the wound healing and the vascular neogenesis. Nowadays, it\r<br />is not known any protocol of tissue regeneration applied to hair\r<br />transplantation, especially if aimed to the reconstruction of the main vascular\r<br />network for the engraftment of transplanted hair and the healing process. The\r<br />aim of the work is to investigate how the application of autologous cellular\r<br />suspension obtained by Rigenera system, mechanical fragmentation procedure\r<br />which allows to obtain a physiological saline solution consisting of a heterogeneous pool of cells rich in adipose derived\r<br />mesenchymalstem cells and growth factors, helps the wound healing and\r<br />engraftment of the transplanted hair. During hair restoration surgery, the\r<br />adipose tissue recovered from the discard of follicular slicing, was processed\r<br />using the Rigenera system. The obtained cell suspension was applied in the area\r<br />of hair transplantation, increasing the natural background of adipocyte lineage\r<br />and raising the amount of growth factors. In addition, the cellular suspension\r<br />was applied to the suture on the occipital region. The cell population was\r<br />characterized by FACS. The monthly evaluation of hair transplantation follow-up\r<br />with photos and the patient’s impressions demonstrates that there is a faster\r<br />healing of the micro-wound and a continuous growth of the transplanted hair\r<br />even two months after the procedure, with a shortening of the dormant phase. In\r<br />conclusion, this new approach aims to integrate regenerative medicine and hair\r<br />restoration surgery in order to improve the outcome for the patient. It would\r<br />be wonderful to continue this research to elaborate on the molecular cause\r<br />behind this satisfying clinical.




Zanzottera, F., Lavezzari, E., Trovato, L., Icardi, A., & Graziano, A. (2014). Adipose Derived Stem Cells and Growth Factors Applied on Hair Transplantation. Follow-Up of Clinical Outcome. Journal of Cosmetics, Dermatological Sciences and Applications, 04(04), 268–274.

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