SdrA, a new DeoR family regulator involved in Streptomyces avermitilis morphological development and antibiotic production

Abstract

The SAV3339 (SdrA) protein of Streptomyces avermitilis, a member of the DeoR family of regulators, was assessed to determine its in vivo function by gene knockdown through the use of cis-encoded noncoding RNA and knockout of the sdrA gene. These analyses revealed that SdrA represents another class of Streptomyces regulator that controls morphological development and antibiotic production. © 2013, American Society for Microbiology.