Elevated glycosyltransferase activities in infected or traumatized hosts: Nonspecific response to inflammation

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Abstract

Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, α2-fucosyltransferase, and α3-fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver during inflammatory processes. Serum sialyltransferase became elevated in bacteria-infected or burned rats and sandfly fever-infected humans, but did not correlate with acute-phase serum protein changes. These data suggest that nonparenchymal liver cells, such as macrophages, may contribute substantially to elevated sialyltransferase activity in the circulation during infection and, as such, represent a general host response to infection and tissue trauma.

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Canonico, P. G., Little, J. S., Powanda, M. C., Bostian, K. A., & Beisel, W. R. (1980). Elevated glycosyltransferase activities in infected or traumatized hosts: Nonspecific response to inflammation. Infection and Immunity, 29(1), 114–118. https://doi.org/10.1128/iai.29.1.114-118.1980

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