Synthesis of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a one-pot Ugi-azide/Pictet-spengler process

Abstract

A series of novel 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β- carbolines were prepared in good to excellent overall yields by an efficient MW-assisted one-pot Ugi-azide/Pictet-Spengler process. This work describes the first synthesis of compounds including both 1,5-disubstituted 1H-tetrazole and 2,3,4,9-tetrahydro-1H-β-carboline heterocyclic systems. © Georg Thieme Verlag Stuttgart · New York.