Human papilloma virus genotype distribution in women with cervical intraepithelial neoplasia

Abstract

Objective: The aim of this study is to identify the prevalence of oncogenic human papillomavirus (HPV) genotypes in women with abnormal smear or cervical HPV infection and histopathological examination of colposcopy-guided biopsies in women with HPV positivity in a southeastern city of Turkey. Material and Methods: One-hundred eighty-nine women who were referred for either HPV positivity or an abnormal smear result were recruited to the study. The prevalence of oncogenic and non-oncogenic HPV genotypes was analyzed according to the histopathological diagnosis of the specimens obtained via cervical smear and colposcopy-guided biopsies. Results: Out of 189 patients, 36 (19,0%) had an abnormal smear result and 153 (81,0%) had a positive HPV test. Out of 153 patients, 33, 9% (n=64) were positive for HPV 16 and/or 18 and 47.1 (n=89) were positive for other HPV genotypes. While 112 patients had positivity for one HPV genotype 21.7% were positive for 2 or more HPV genotypes. The most frequent HPV genotypes were HPV 16 (24.2%), HPV 18 (8.2%), HPV 51 (7.8%), HPV 39 (5.9%) and HPV 53 (4.6%). The highest prevalence of HPV16-18 was in the 30-49 age group. HPV 16 and 18 positivity were recorded in 20.2% of the cases with benign pathology while the prevalence was 34.7% in CIN I, 57.1% in CIN II-III and 100% in cases with invasive cervical carcinoma. Conclusion: HPV 16 and 18 were the most prevalant oncogenic HPV genotypes in the studied patient group and their presence was related with the severity of the cervical pathology.