Inflammatory injury to the neonatal brain - what can we do?

9Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

Abstract

Perinatal brain damage is one of the leading causes of life long disability. This damage could be hypoxic-ischemic, inflammatory, or both. This mini-review discusses different interventions aiming at minimizing inflammatory processes in the neonatal brain, both before and after insult. Current options of anti-inflammatory measures for neonates remain quite limited. We describe current anti-inflammatory intervention strategies such as avoiding perinatal infection and inflammation, and reducing exposure to inflammatory processes. We describe the known effects of anti-inflammatory drugs such as steroids, antibiotics, and indomethacin, and the possible anti-inflammatory role of other substances such as IL-1 receptor antagonists, erythropoietin, caffeine, estradiol, insulin-like growth factor, and melatonin as well as endogenous protectors, and genetic regulation of inflammation. If successful, these may decrease mortality and long-term morbidity among term and pre-term infants.

Cite

CITATION STYLE

APA

Ofek-Shlomai, N., & Berger, I. (2014, April 1). Inflammatory injury to the neonatal brain - what can we do? Frontiers in Pediatrics. Frontiers Media S.A. https://doi.org/10.3389/fped.2014.00030

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free