New perfluorophtalate complexes of platinum(II) with chemotherapeutic potential

0Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Two new platinum(II) complexes have been synthesized and their anti-tumour and anti-HIV activities have been evaluated. The new complexes are: (i) cis-tetrafluorophthalate-ammine-morpholine-platinum(II) or MMF3 and (ii) cis-tetrafluorophthalate-ammine-piperidine-platimun(II) or MPF4. They were characterized by elemental analysis, IR spectra and 1H and 13C NMR spectra. They were tested against five human ovarian carcinoma cell lines, viz., CH1, CH1cisR, A2780, A2780cisR and SKOV-3. They were less active than cis-platin and showed cross-resistance with cis-platin in the CH1cisR and A2780cisR acquired resistance lines. They were also tested for possible anti-HIV activity using the HIV-I IIIB virus ant C8166 cells, but they were inactive compared with AZT.

Cite

CITATION STYLE

APA

De Oliveira, M. B., Milled, J., Banks, R. E., Kelland, L. R., McAuliffe, C. A., Mahmood, N., & Rowland, I. J. (1996). New perfluorophtalate complexes of platinum(II) with chemotherapeutic potential. Metal-Based Drugs, 3(3), 117–122. https://doi.org/10.1155/MBD.1996.117

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free