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Due to the lack of prophylactic vaccines and effective treatment strategies against numerous public health conditions, viral infections remain a serious threat to global public health and socioeconomic development. The current ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, against which there is no prophylactic vaccine or licensed antiviral agents, underscores the need to continuously identify novel/effective treatment strategies against these infectious agents. Plants and plant-derived compounds have immensely contributed to the fight against numerous health conditions by providing bioactives that possess potent antimicrobial attributes, including antiviral activities. One such plant that has gathered much interest, due to its multiple medicinal properties, is the Nigella sativa plant, a flowering plant belonging to the family Ranunculacea, which is native to various regions of the world. In this chapter, we discuss the antiviral activities of N. sativa against critical viral pathogens, focusing more on the SARS-CoV-2 virus, the etiologic agent of the current unparalleled coronavirus disease (COVID-19) pandemic.
Jassey, A., Imtiyaz, Z., Jassey, S., Imtiyaz, M., & Rasool, S. (2021). Antiviral effects of black seeds: Effect on COVID-19. In Black Seeds (Nigella sativa): Pharmacological and Therapeutic Applications (pp. 387–404). Elsevier. https://doi.org/10.1016/B978-0-12-824462-3.00004-4