Existe associação entre vitamina D e fibrose hepática em pacientes com hepatite C crônica?

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Abstract

Background – Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. Objective – This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection. Methods – Cross-sectional study composed of patients with chronic hepatitis C. All patients underwent vitamin D 25 dosage and anthropometric data analysis. Liver biopsy was performed in a maximum 36-month period before inclusion in the study. Results – Of the 74 patients included in the study, 45 (60.8%) were women, mean age was 57.03±9.24 years, and 63 (85.1%) were white. No association was observed between the serum levels of vitamin D and inflammatory activity (P=0.699) nor with the degree of liver fibrosis (P=0.269). Conclusion – In this study, no association was observed between vitamin D and inflammatory activity, as well as the degree of liver fibrosis, in patients with chronic hepatitis C.

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Oliveira, K. D. S., Buss, C., & Tovo, C. V. (2017). Existe associação entre vitamina D e fibrose hepática em pacientes com hepatite C crônica? Arquivos de Gastroenterologia, 54(1), 57–59. https://doi.org/10.1590/S0004-2803.2017v54n1-11

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