MSWA-ResNet: Multi-Scale Wavelet Attention for Patient-Level and Interpretable Breast Cancer Histopathology Classification

Abstract

Breast cancer histopathological classification is critical for diagnosis and treatment planning, yet manual assessment remains time-consuming and subject to inter-observer variability. Although deep learning approaches have advanced automated analysis, image-level data splitting may introduce data leakage, and spatial-domain architectures lack explicit multi-scale frequency modeling. This study proposes MSWA-ResNet, a Multi-Scale Wavelet Attention Residual Network that embeds recursive discrete wavelet decomposition within residual blocks to enable frequency-aware and scale-aware feature learning. The model is evaluated on the BreakHis dataset using a strict patient-level protocol with 70/30 patient-wise splitting, five-fold stratified cross-validation, ensemble prediction, and hierarchical aggregation from patch to patient level. MSWA-ResNet achieves 96% patient-level accuracy at 100×, 200×, and 400× magnifications, and 92% at 40×, with F1-scores of 0.97 and 0.94, respectively. At 200× and 400×, accuracy improves from 0.92 to 0.96 and F1-score from 0.94 to 0.97 over baseline CNNs while maintaining 11.8–12.1 M parameters and 2.5–4.8 ms inference time. Grad-CAM demonstrates improved localization of diagnostically relevant regions, indicating that explicit multi-scale frequency modeling enhances accurate and interpretable patient-level classification.