Tumor cells exhibit an upregulation in glycolysis, glycogen metabolism, and gluconeogenesis as opposed to normal cells.The metabolic reprogramming underlying the Warburg effect and other changes in glucose metabolism are driven by several oncogenes and tumor suppressors.Numerous therapies based on cancer metabolism have been developed but have yet to show success in clinical trials.
Bose, S., & Le, A. (2018). Glucose metabolism in cancer. In Advances in Experimental Medicine and Biology (Vol. 1063, pp. 3–12). Springer New York LLC. https://doi.org/10.1007/978-3-319-77736-8_1