Transcription factors and chromatin modifiers are known to contribute to cell specification. However, whether and how they jointly act is poorly understood. In this issue of Cell Stem Cell, Ninkovic et al. show that Pax6 and Brg1 cooperate to modulate gene expression in order to direct neurogenic fate in the olfactory bulb. © 2013 Elsevier Inc.
Jaglin, X. H., & Fishell, G. (2013, October 3). A foot in the door: How the chromatin modifier Brg1 and Pax6 jointly potentiate adult neurogenesis. Cell Stem Cell. Cell Press. https://doi.org/10.1016/j.stem.2013.09.013