The value of luteal support with progesterone in gonadotropin-induced cycles

11Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Objective: To evaluate the effect of luteal support with vaginal P suppositories in hMG- and hCG-induced cycles. Design: Between March 1988 and February 1989 patients did not receive luteal support, while between March 1989 and January 1990 P was given routinely in the luteal phase. Induction protocol and patient selection remained otherwise unchanged. Setting: Infertility clinic of a tertiary care hospital. Patients: Twenty-seven patients with hypogonadotropic amenorrhea (World Health Organization [WHO] group I) (11 women with luteal support, 16 women without) and 102 patients with euprolactinemic clomiphene citrate (CC)-resistant anovulation (WHO group II) (52 women with luteal support, 50 women without). Intervention: Vaginal P suppositories 200 mg/d in the luteal support group. Main Outcome Measures: Pregnancy rate (PR), pregnancy outcome. Results: The overall PR in 118 cycles with luteal support was 26.3% whereas 10.4% pregnancies were achieved in 115 cycles of the control group. The influence of luteal support was more pronounced in patients with CC-resistant anovulation (25.2% versus 6.9%) than in patients with hypogonadotropic amenorrhea (33.3% versus 21.4%, not significant). The abortion rate was not significantly changed. Conclusion: Luteal support with P increases the PR after hMG and hCG induction. The need for supplementary P seems to be related to the underlying cause of ovarian disturbance.

Cite

CITATION STYLE

APA

Hamilton, C. J. C. M., Jaroudi, K. A., & Sieck, U. V. (1993). The value of luteal support with progesterone in gonadotropin-induced cycles. Fertility and Sterility, 60(5), 786–790. https://doi.org/10.1016/S0015-0282(16)56277-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free