A multicatalytic approach that combines a bifunctional Brønsted base-squaramide organocatalyst and Ag+ as Lewis acid has been applied in the reaction of unactivated ketones with tert-butyl isocyanoacetate to give chiral oxazolines bearing a quaternary stereocenter. The formal [3+2] cycloaddition provided high yields of the corresponding cis-oxazolines with good diastereoselectivity and excellent enantioselectivity, being applied to aryl-alkyl and alkyl-alkyl ketones.
CITATION STYLE
Martínez-Pardo, P., Blay, G., Muñoz, M. C., Pedro, J. R., Sanz-Marco, A., & Vila, C. (2018). Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis. Chemical Communications, 54(23), 2862–2865. https://doi.org/10.1039/c8cc00856f
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