Mutalomycin, a new polyether antibiotic taxonomy, fermentation, isolation and characterization

Abstract

Mutalomycin is a new metal-complexing polyether antibiotic produced by a strain of Streptomyces mutabilis NRRL 8088. The metabolite, a monocarboxylic acid, was isolated as the sodium salt C41H69NaO12. The structure of this polyether was estabhshed by X-ray analysis of its potassium salt C41H69NaO12. Mutalomycin contains six heterocyclic rings and is structurally related to nigericin. The metabolite is active against gram-positive bacteria and Eimeria tenella (chicken coccidiosis). © 1977, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.