O3-01-03: Caring for Patients with Young Onset Dementia: What Factors Need Close Attention?

  • Hoon Linda L
  • Hui Zhang A
  • Mei N
  • et al.
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Background: Caring for persons with dementia often contribute to high levels of caregiver burden (CB). Demographic, cognitive and clinical characteristics and age of onset may have an impact on CB. Thus, it is important to recognize clinical variables at baseline that will aid in predicting future levels of CB. Methods: 150 patients were studied, 54 were classified as young onset dementia (YOD) and 96 as late onset dementia (LOD). Zarit Burden Inventory (ZBI) was used to measure the Level of CB and Neuro-Psychiatry Inventory - Questionnaire (NPI-Q) was used to measure caregivers'distress level in response to participants'neuro-psychiatry presentation. Cognitive function was measured using Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Characteristics of caregivers with high and low ZBI were analysed. Results:The mean age of patients with YOD and LOD were 61.9 years and 77.2 years respectively. The mean MMSE scores (17.32 vs. 19.08; p=0.236) and MOCA scores (16.65 vs. 16.99; p=0.995) were not statistically different between the two groups. A logistic regression was performed to ascertain the factors that are associated with a higher caregiver burden. Family history of dementia (22.2%), presence of BPSD (21.2%), severity of disease, MMSE, ADCS-ADL and NPI-Q scores were factors associated with the likelihood that caregivers would report a high level of caregiver burden. The model explained 50% of the variance in the high Zarit scores and correctly classified 83% of cases. In particular, caregivers for individuals with YOD were almost 3 times more likely to experience high levels of caregiver burden. Conclusions: Intervention programs with strategies that provide comprehensive support for caregivers of YOD should be a priority in the holistic management of dementia.




Hoon Linda, L. L., Hui Zhang, A. S., Mei, N. M., Choong, T. M., Noi Koh, S. A., Silva, E., & Kandiah, N. (2016). O3-01-03: Caring for Patients with Young Onset Dementia: What Factors Need Close Attention? Alzheimer’s & Dementia, 12, P280–P281. https://doi.org/10.1016/j.jalz.2016.06.508

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