Molecular epidemiology of vancomycin-resistant Enterococcus faecium in Argentina

24Citations
Citations of this article
54Readers
Mendeley users who have this article in their library.

Abstract

Objective: To characterize the mechanism of glycopeptide resistance and to determine the genetic relatedness among strains by pulsed-field gel electrophoresis (PFGE) in vancomycin-resistant Enterococcus faecium from Argentina. Materials and methods: A total of 189 vancomycin-resistant single-patient isolates of Enterococcus faecium recovered between January 1997 and December 2000 from 30 hospitals in Argentina were studied. Minimum inhibitory concentrations were determined by the agar dilution method and van genes were detected by PCR. PFGE was used for molecular typing. Results: All isolates except three (vanB) were of genotype vanA. For 189 vancomycin-resistant Enterococcus faecium, SmaI-PFGE indicated 35 clonal types. Most of the isolates (56%) belonged to the same clonal type 1, which was present in 19 hospitals and dominant in 17. Conclusions: The emergence of vancomycin-resistant Enterococcus faecium in Argentina seems to be related to the intra- and inter-hospital dissemination of an epidemic clone carrying the vanA element. © 2006 International Society for Infectious Diseases.

Cite

CITATION STYLE

APA

Corso, A. C., Gagetti, P. S., Rodríguez, M. M., Melano, R. G., Ceriana, P. G., Faccone, D. F., & Galas, M. F. (2007). Molecular epidemiology of vancomycin-resistant Enterococcus faecium in Argentina. International Journal of Infectious Diseases, 11(1), 69–75. https://doi.org/10.1016/j.ijid.2006.02.003

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free