Size Analysis Of Small Metal Nanoparticles Using Single Particle Icp Mass Spectrometry

Abstract

For Size Analysis Of Small Nanoparticles (I.E., Nanoparticles Smaller Than 10 Nm) Using Spicp-Ms, Two Approaches Were Employed To Improve The Signal-To-Noise Ratio Of Ion Signals Emanating From Small Nanoparticles. The First One Was Enhancement Of The Instrumental Sensitivity Using A Desolvating System. The Second Approach Was Separation Of The Ion Signals From Background Signals Through A Deconvolution Method. A Combination Of These Approaches Enabled Us To Measure 5 Nm Gold Nanoparticles, And The Calculated Size Detection Limit Was 3.8 Nm