Antimicrobial and anthelmintic activities of some newly synthesized triazoles

Abstract

Objective: The objective of this work is to synthesize and evaluate some novel 1,2,4-triazoles. Methods: Procedure includes synthesis of triazole compounds followed by biological evaluations. The synthesis was carried out in six steps with p-bromobenzoic acid as starting material and converting to ester and then to hydrazide. Hydrazide was then converted to 4-amino triazole. The amino triazole was then linked to different secondary amines using chloroacetyl chloride as the linking agent. All the synthesized compounds were characterized through Fourier transform infrared spectroscopy, gas chromatography-mass spectroscopy, and nuclear magnetic resonance. Further, the compounds were taken out for biological evaluations. To explore their effects, experiments were conducted on various micro- as well as macro-organisms. The toxicity profile was also tested in accordance with OECD 425 guideline on Wistar albino rats. Results: The compounds were examined for antibacterial as well as antifungal activities. Among the all compound T71, T73, and T75 exhibited antibacterial activity, and compound T71 showed antifungal activity as well. The evaluation was also carried out for anthelmintic activities. The compounds were treated on Pheretima posthuma at various concentrations to explore their vermifuge and vermicidal action. The triazole linked with 1-methylpiperazine was found to have comparable activity to that of reference standards. Conclusion: Triazoles are a most potent assemblage of fungal retardants. But depending on their substituents, they also have diverse pharmacological values. In this study, the compound T71 showed promising antimicrobial as well as anthelmintic action. Hence, it can be considered as a lead compound for further researches.