Inter-laboratory harmonization of microsphere immunoassays for SARS-CoV-2 antibody detection in contrived dried blood spots and oral fluids

Abstract

The establishment of common research and clinical laboratory methodologies for the assessment of SARS-CoV-2 antibody levels in different biospecimen types is of paramount importance in estimating immunity to COVID-19 infections in communities and populations. In this report, we evaluated multiplex immunoassay protocols to enable comparisons between two readily attainable biospecimen types, namely, dried blood spots (DBS) and oral fluids (OF), which are employed in population-scale antibody monitoring of SARS-CoV-2 antibody titers and virus-neutralizing potential.