Avaliação do Uso de Amidos Aniônicos Hidrolisados como Estabilizantes em Nanocápsulas Poliméricas para Formulações Tópicas

Abstract

The purpose of this work was to introduce modified hydrolyzed starches (anionic) as surfactant in a formulation for the encapsulation of benzophenone-3 with a polymer matrix of poly(ε-caprolactone) (PCL), including the study of the influence from the surfactant on the physicochemical characteristics of nanoparticles. The nanoparticles were prepared via interfacial deposition of the pre-formed polymer, using an experiment design for the mixtures. The starches were initially hydrolyzed via an enzymatic process and surface tension measurements were performed to assess the ability of surfactant aqueous solutions of hydrolyzed starch for application in nanocapsule formulations. The results indicated that the starches can be employed as surfactant in the formulations, without significantly altering properties such as diameter, polydispersity and encapsulation efficiency.